Safety data sheet for Tetrahydrofuran
CAS 109-99-9
This is the free preview of a draft SDS for Tetrahydrofuran — Sections 1, 2 and 9, generated from the sources named below. The full 16-section draft, with your own company in Section 1, is $5 per document.
Typically documented by: Laboratory solvent, polymer processing.
Draft safety data sheet — preview
Sections 1, 2, 9 of 16
- CAS number
- 109-99-9
- Molecular formula
- C4H8O
- Molecular weight
- 72.11 g/mol
- Signal word
- Danger
Hazard classification
- GHS02 — Flammable
- GHS07 — Health hazard — irritant
- H225: Highly Flammable liquid and vapor.
- H302: Harmful if swallowed.
- H319: Causes serious eye irritation.
- H335: May cause respiratory irritation.
- H336: May cause drowsiness or dizziness.
Section 1 — Identification
1.1 Product identifier
Product identifier: Tetrahydrofuran
Chemical name (IUPAC): oxolane
CAS number: 109-99-9
PubChem CID reference: 8028
Synonyms: TETRAHYDROFURAN; Oxolane; Furanidine; Furan, tetrahydro-; Tetramethylene oxide; Hydrofuran; Oxacyclopentane; 1,4-Epoxybutane; Tetrahydrofuranne; Tetraidrofurano
1.2 Relevant identified uses of the substance or mixture and uses advised against
Relevant identified uses: Laboratory reagent, industrial processing aid, formulation component, and internal product-stewardship review subject to supplier confirmation.
Uses advised against: Consumer, medical, food, or any other use not covered by the supplier's label, technical instructions, or exposure scenario.
Section 2 — Hazards Identification
2.1 Classification of the substance or mixture
Classification basis: OSHA 29 CFR 1910.1200 Appendix A, aligned to the GHS Rev. 7 hazard classes.
Classification: Flammable Liquid, Category 2 (Flam. Liq. 2) [H225]
Classification: Acute Toxicity, Category 4 — Oral (Acute Tox. 4 (Oral)) [H302]
Classification: Eye Irritation, Category 2 (Eye Irrit. 2) [H319]
Classification: Specific Target Organ Toxicity, Single Exposure, Category 3 (STOT SE 3) [H335]
Classification: Specific Target Organ Toxicity, Single Exposure, Category 3 (STOT SE 3) [H336]
2.2 Label elements
Signal word: Danger
GHS pictograms: GHS02 (Flammable), GHS07 (Exclamation)
Hazard statement: H225: Highly Flammable liquid and vapor.
Hazard statement: H302: Harmful if swallowed.
Hazard statement: H319: Causes serious eye irritation.
Hazard statement: H335: May cause respiratory irritation.
Hazard statement: H336: May cause drowsiness or dizziness.
Precautionary statement: P210: Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
Precautionary statement: P264+P265: Wash hands thoroughly after handling. Do not touch eyes.
Precautionary statement: P280: Wear protective gloves, protective clothing, eye protection, face protection, and hearing protection.
Precautionary statement: P303+P361+P353: IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower.
Precautionary statement: P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
Precautionary statement: P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
Section 9 — Physical and Chemical Properties
9.1 Information on basic physical and chemical properties
Physical form: Liquid
Appearance: Colorless, mobile liquid
Odor: Ether-like odor
Boiling point: 65°C (149°F) at 1013 hPa
Melting point: -108.4°C (-163°F)
Flash point: -14.5°C (6°F) closed cup
Density: 0.8833 g/cm³ at 25°C
Vapor pressure: 152 hPa at 15°C
Water solubility: Miscible
Log Pow (log Kow): 0.46
Vapor density: 2.5 (air = 1)
Lower explosive limit: Not available
Upper explosive limit: Not available
Auto-ignition temperature: 321°C (610°F)
Viscosity: 0.53 cP at 20°C
pH: Not available
9.2 Other information
Other information: Additional classification-supporting physical hazard data should be confirmed from the customer-specific product specification where required.
Sources
- ECHA C&L Inventory — harmonised CLP entry
- PubChem — GHS classification
- PubChem — compound record
- PubChem — names and identifiers
- PubChem — regulatory information
- PubChem — toxicity data
- PubChem — transport information
Sections 1.3 and 1.4 are withheld here because the supplier and emergency contact blocks carry your own company details in the draft you buy. Every draft needs review by a competent person before it is issued.
Measured values for Tetrahydrofuran, and where each one comes from
35 measured values for 12 properties, read from 4 public databases. On 5 properties the records differ. Each reading is shown with its own record. Follow any record to read the value at its source.
Boiling point
4 records, 65 to 66 °C
Used with vapour pressure to judge how readily the substance reaches the air you breathe.
- 151 °F
- NIOSH Pocket Guide
- 65 °C @760 [mm Hg]
- PAC Chemical Database, U.S. Department of Energy
Melting point
4 records agree
Fixes the physical state at handling temperature, which the label and the transport class depend on.
- -108.44 °C
- Hazardous Substances Data Bank (HSDB)
- -163 °F
- NIOSH Pocket Guide
- -163.3 °F
- OSHA Occupational Chemical Database
Flash point
3 records agree
The lowest temperature at which the liquid gives off enough vapour to ignite. It decides the GHS flammable liquid category.
- 6 °F (closed cup); -4 °F (open cup)
- Hazardous Substances Data Bank (HSDB)
Auto-ignition temperature
1 record
The temperature at which the substance ignites with no spark or flame. It sets safe surface and process temperatures.
- 321 °C (610 °F)
- Hazardous Substances Data Bank (HSDB)
Explosive limits
2 records differ
The vapour concentration range in air that will burn. Below the lower limit and above the upper limit it will not.
- LEL: 1.8%; UEL: 11.8%
- Hazardous Substances Data Bank (HSDB)
- Tetrahydrofuran (THF) vapor forms explosive mixtures with air at concentrations of 2 to 12% (by volume)
- Hazardous Substances Data Bank (HSDB)
Vapour pressure
5 records differ
The higher it is, the faster the substance evaporates into the workplace air at room temperature.
- Vapor pressure = 0.06 atm at 0 °C, 0.11 atm at 10 °C, 0.173 atm at 20 °C, 0.26 atm at 30 °C
- Hazardous Substances Data Bank (HSDB)
- 1.62X10+2 mm Hg at 25 °C
- Hazardous Substances Data Bank (HSDB)
- 132 mmHg
- NIOSH Pocket Guide
- 75 [mm Hg] @9 °C
- PAC Chemical Database, U.S. Department of Energy
Vapour density
2 records differ
Above 1 the vapour sinks and collects in pits, sumps and low enclosed spaces.
- 2.5 (Air = 1)
- Hazardous Substances Data Bank (HSDB)
Density
5 records differ
Needed to convert between mass and volume on the label, in transport papers and in a spill estimate.
- 0.8833 g/cu cm at 25 °C
- Hazardous Substances Data Bank (HSDB)
- Saturated liquid density: 55.230 lb/cu ft; saturated vapor pressure: 2.913 lb/sq in; saturated vapor density: 0.03660 lb/cu ft (all at 75 °F)
- Hazardous Substances Data Bank (HSDB)
- 0.8833 @25 °C
- PAC Chemical Database, U.S. Department of Energy
Solubility
5 records, each a different case
Determines spill behaviour, the right extinguishing media and the correct first-aid rinse.
- Miscible with alcohols, ketones, esters, hydrocarbons, and ethers
- Hazardous Substances Data Bank (HSDB)
- Very soluble in acetone, benzene, ether, ethanol, and chloroform
- Hazardous Substances Data Bank (HSDB)
- 30% IN WATER AT 25 °C
- Hazardous Substances Data Bank (HSDB)
- Miscible in water at 25 °C
- Hazardous Substances Data Bank (HSDB)
- Miscible
- NIOSH Pocket Guide
Partition coefficient (log Kow)
1 record
Indicates whether the substance accumulates in fat or in water, which drives the environmental sections.
- log Kow = 0.46
- Hazardous Substances Data Bank (HSDB)
Viscosity
1 record
Governs how far a spill spreads and how fast it soaks into a surface or a sorbent.
- 0.53 cP at 20 °C
- Hazardous Substances Data Bank (HSDB)
Odour
2 records, each a different case
Odour is a warning property only. Many substances are hazardous well below the concentration you can smell.
- Ether-like odor
- Hazardous Substances Data Bank (HSDB)
- FAINT FRUITY ODOR
- Hazardous Substances Data Bank (HSDB)
These are the public records read for Tetrahydrofuran, published here unchanged. Where two records disagree, the draft you buy states the value and names the record behind it, so a reviewer can see what was chosen. Every draft needs review by a competent person before it is issued.
Get the full draft SDS for Tetrahydrofuran
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